Catch 22 - I.e. Last Entered Value In A Given Range

let's suppose I have a prefixed range like A1:A300 in which periodically I need to enter some records (normally numbers but also sometime blank cells - i.e. void no entries); so imagine you have an array of cells in which I want to catch by mean of a formula or a macro the last entered significative record (i.e. a number); the objective is obviously to catch the last significative record in that given range having numbers in it (i.e. leaving out any blank cells in between); no other clues to approach the problem are given: do you think it's possible to sort out somehow this tricky problem ?

example:

1
34
67
#
45
#
#
545
#
22

where # stands for blank cell

how to catch 22?